Some trees that bees have moved into have real structural issues, either from rot, termites, rot and termites, lightening that struck the tree and killed part of the tree, etc...
Bees may be able to hollow out a rotten section a little bit to expand the colony. I've seen them chew other materials to expand the hive like pile insulation and foam insulation, but a solid section of tree in my opinion is too much for them to work on. A hollow that has soft wood, they could do.
Honeybees are not classified as a structural pest.
...JP