If you cut it out and freeze it, it makes great fishing bait. :-D
If you just uncap it, any adult mites in there will just re-enter the hive. Freezing is a good idea to kill the mites. Freeze, then scratch the cappings. They do fine on their own, though, usually without scratching.
If there is only one frame of drone brood, they will usually draw out a foundationless frame as drone comb. Sometimes they will draw half worker brood, then you just have to cut out the drone stuff if possible.
Rick