The comb is not as fragile once it ages a little bit, I have even seen a big difference in a couple of weeks with mine.
If they attach it on at least 3 sides I think its fine, I know I turn mine on its side at times if I am looking for something or holding towards my husband to help look for the queen etc.
Of course I would only do that with a frame I know can handle that and you know pretty quickly how fragile a comb is and I wouldn't do it on a hot day either when the wax is warm.
Are you sure they are drone cells? Natural comb can appear to have drone cells when they are just storage cell. Are they capped?
I know from reading alot on this forum that many times a colony on natural comb will build alot of drone comb at first and if you just leave it they will move on.
I haven't seen much of it in my hives, really just one that has a frame of capped drone comb and I am on all foundationless frames.