Something about this doesn't add up ...
When a colony is first introduced to a box with an OMF - yes, then it can happen - because the bees don't know where their entrance is. Likewise, if you suddenly change the entrance (as I do, when spinning the hive around on a turntable when using the Cloake Board method) - again it can happen, because the bees become confused. Easy enough to fix in both cases with some form of closure.
But when a virgin queen goes out to mate, she doesn't do so on her own - there are bees with her on the outward trip, and often on the return journey too - and those bees aren't confused about where their entrance is.
I often see a large number of bees on the hive face, fanning away to help guide the queen in - after all, it's in the colony's interest to ensure a safe return - they've invested a lot of energy and resources into creating that queen. My returning mated queens can even negotiate an anti-robbing screen, as well as find their way to the box entrance itself - no doubt with the assistance of 'entourage bees'.
I've never once had this kind of problem with a queen - and I've never heard of this happening until now. Indeed, doesn't the lion's share of mating take place from mating nucs (?), and these either have no OMF or (in the case of mini-nuc boxes) a very token one - but I assume we're not talking about those tiny boxes here ...
LJ