Aroc, I raise queens. I create a walk away split ya might say, except there is no queen in either box. I use five frame Nucs for mating nucs. I open the nuc every other day. I have to watch for rogue queens, queen cells, I add cell larva frames, a day later I remove and add larva.,,,,,, constant opening of the nucs.
My point is this: I am opening my mating nucs constantly, at least every other day. Also I have established Nucs inwhich I open every week or so to check status, that is, amount of eggs laid.
Another point I wish to make: these are my bees with my chosen genetics which one is gentleness. So what works for me, constant interruptions, may not work with your bees.
However, if your bees abscond or the queen quits laying because of opening a hive once in ten days, I say your better off without those picky bees anyway. Go for it, open the split!!!
Blessings