ummm the bounce around thing about .22s ...sorry, another mostly-myth. .. huge amount of BS myth concerning the .223 rem (or 5.56x45) going squirrelly upon entering a body.
.22 LR does tend to fragment or deflect when hitting a bone more than larger hunks of metal, and of course any jacketed round. However, it doesn't bounce around. Another mostly-myth is that the .22 short will penetrate a skull and then "bounce around". It doesn't. When it doesn't exit, it usually causes cracking/breaking the skull on the opposite side of the entry. It can deflect if striking the interior of the skull at a low enough angle, but it still doesn't really bounce.
Really strange things happen with bullets, though. Sometimes you can find exceptions to fit the myth. I personally know of one case where a man was shot in the forehead and the bullet traveled for a short distance between skin and skull and exited before it reached the temple. Dude literally took 4 stitches to fix him up. 2 on the entry wound and the other 2 on the exit. (and a couple of weeks in observation at a mental hospital). One of my aunts was the shooter.
It knocked him out cold, so it counts as a one shot stop for a .25 ACP.
Correction: Shoot until the threat is stopped/neutralized. Whether the target lives or dies is irrelevant. "They" implies a person. The target is not a person until they are not a threat.
Hopefully, they stop being a threat peacefully.
There is a weird thing with .22LR that is true .. the "it kills you later" thing ... but the reason is that the wound is often viewed as being not as serious as it really is, and taking the doctor by surprise a day or two later. ... itty bitty hole with a surprisingly large area of hydraulic disturbance in the surrounding tissue.