Bob,
I see this in a lot of hives that I do cutouts. Usually it is in large old hives.
I recommend that you rearrange the hive and try to put the bulk of the brood back together near the entrance, put the frames with pollen near it. I also recommend that you put an empty drawn frame in the middle of the brood to give the queen a place to lay. As soon as she fills it up, add another one.
If you want, cut out some of the honey comb, leave the pollen (pollen makes your honey look cloudy and gives it a funny taste).
Jim Altmiller