Thank you to those who have responded to my question and thank you, in advance, to those of you who may be answering in the future. Here is what I have decided to do, at least for today.
I am going to run an experiment (inquiring minds need to know) in which I am wiring up 5 deep frames with 3 strands and 5 frames with only two strands. Bear in mind that these are American deep frames at +/- 9". Numbering the 4 holes from top to bottom, we have holes 1, 2, 3, and 4. On the 3-strand frames, I am wiring through holes 2, 3, and 4. On the 2-strand frames, I am wiring through holes 2 and 4.
With both options, I have skipped hole #1 entirely as it is only about 3/4" from the sideways-turned wedge. Once the comb is built around both sides of the wedge, it should be very secure at that point without the wire.
One advantage I am seeing already: the fewer strands run, the easier it is to get good tension. I have a wiring jig that squeezes the end bars. Once wired and released from the jig, wire tension increases. However, with 4 strands, it is still difficult to get good tension. (I do not own a crimping tool, that I know of. There may be one hiding somewhere that I've forgotten but it is not handy at the moment if it exists at all.)
Another POSSIBLE advantage is that with fewer wires, it will be easier to cut out queen cells. We'll see over the next couple of years as the experiment progresses.
Further advantages may come to light over the next couple of years. However, the point may be moot for me as once my supply of eyelets and/or wire is depleted, I intend to switch to monofilament line as suggested by little john and others elsewhere for the sake of cost efficiency and simplicity. With monofilament, it may be just as easy and cheap to wire with 4 strands. Either way, I hope that within a couple of years, there will be at least some anecdotal evidence to indicate whether fewer strands make that much of a negative difference to warrant using 4.
PRELIMINARY RESULTS: (this is simply a hypothesis at this point) It looks as if 2 strands MAY be too flimsy. The frames with 3 strands look as if that will be just about perfect, bearing in mind that the upper end of the comb is attached by a side-turned wedge. I'