A can of raid could end this all, or for that matter a nickel to seal up their hole could end this all. It might save you a few thousand but their counter offer might be to remove the costs of an exterminator form the end price.
House siding is just held on by nails, with the above piece covering the nails to the lower one. Smoke the bees, remove the siding, take out the wall and remove the comb. Rubber bands can be used to hold the come in place on empty frames and they can be slid into a deep easily. Putting the house back together is another issue.
If you feel removing them is best then just close up the hole.