'Treatment difference' as in:
1) how to set up the colony ?
or
2) treatment for mites, etc ?
If # 1, setting up a nuc is simplicity itself, place the five (or however many) frames in the center of a ten (or more) frame box, being careful of the queen; you probably should remove ALL the frames from the bigger box, then transfer from the nuc two or three frames together till you have them all in, in the same order as in the nuc, then fill out the sides with either drawn combs (preferable if you have them) or full sheets of foundation
Make sure they have adequate feed, a quart jar of 1:1 over the hole in the inner cover, inside an empty medium, is VEERY good insurance against a stretch of bad weather
If # 2..........check in a few weeks and treat as needed.